The aim of WorkPackage 2 is to identify novel peroxisomal transporters and to analyze their function.
We will use:
- proteomics approaches using purified peroxisomal membrane fractions
- proteomic analyses on affinity-purified complexes of Pex19, the receptor for peroxisomal membrane proteins
- in vivo screens to identify proteins that have the capacity to transport various molecules across peroxisomal membranes
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