This WorkPackage aims to establish the role of peroxisome interaction and communication in human health and disease using knowledge generated in WP1 and WP2.

We will use discoveries in glycosomes to screen for drug targets for trypanosomiasis.

Information on the role of functional interactions of peroxisomes with other organelles in malnutrition may give leads for novel therapeutic interventions. Also, we will study how and why malnutrition causes the loss of liver peroxisomes and how this compromises mitochondrial function. Finally, the knowledge generated in WP1 and WP2 will be used to identify and characterize human disorders caused by defects in genes encoding peroxisomal contact site or transporter proteins.

This WP aims to establish the role of peroxisome interaction and communication in human health and disease using knowledge generated in WP1 and WP2.

We will:

• use discoveries in glycosomes to screen for drug targets for trypanosomiasis
• generate information on the role of functional interactions of peroxisomes with other organelles in malnutrition, which may give leads for novel therapeutic interventions
• study why malnutrition causes the loss of liver peroxisomes and compromises mitochondrial function
• identify and characterize human disorders caused by defects in genes encoding peroxisomal contact site or transporter proteins

Information on the role of functional interactions of peroxisomes with other organelles in malnutrition may give leads for novel therapeutic interventions. Also, we will study how and why malnutrition causes the loss of liver peroxisomes and how this compromises mitochondrial function. Finally, the knowledge generated in WP1 and WP2 will be used to identify and characterize human disorders caused by defects in genes encoding peroxisomal contact site or transporter proteins.

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