ESR7-DE: Glycosomal membrane contact sites in trypanosomes

Reference: ESR7-DE

A PhD position is available at the Department of Systems Biochemistry, Ruhr-University of Bochum, Bochum, Germany
Project title: Glycosomal membrane contact sites in trypanosomes
Description:

  • Characterisation of the ATAD1/Msp1-derived membrane contact site (MCS) and identification of novel Trypanosoma MCS proteins using proteomic approaches (Affinity isolated protein complexes of ATAD1/Msp1 and Pex11) and by screening for trypanosomal homologues of newly identified MCS proteins.
  • Validation of the suitability of selected MCS proteins as potential drug targets (RNAi knockdown/CRISPR in Trypanosoma, metabolomics icw MS-omics, systems biology models (in cooperation with UMCG).
  • Screening of drug/compound library (in cooperation with Novartis Pharma AG) for specific inhibitors of Trypanosoma ATAD1/Msp1 ATPase activity.

Location: Bochum, Germany
Supervisor: Prof. Dr. R. Erdmann (ralf.erdmannATrub.de)
Co-supervisors: Dr. D. Hoepfner, Novartis Pharma AG & Prof. Dr. B. Warscheid, University of Freiburg
Planned secondments: University of Freiburg, Novartis Pharma AR, Oroboros Instruments
Required subject specific skills and expertise: a master’s degree in life sciences/biology (molecular cell biology, biochemistry, biomedicine). Experience in cell culture and fluorescence microscopy is advantageous but not mandatory.
Application deadline: 28/10/2018
Starting date:  April 1, 2019

Application form ESR 7

The previous deadline for applications has been extended until October 28.

Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline

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