ESR6-DE: Novel transporters of Trypanosoma glycosomes

Reference: ESR6-DE

A PhD position is available at the Department of Systems Biochemistry, Ruhr-University of Bochum, Bochum, Germany
Project title: Novel transporters of Trypanosoma glycosomes
Description:

  • Identification of Trypanosoma transporters using proteomics approaches (proteomics of purified organelle membranes and isolated Pex19 complexes) and in silico screening of homologs of known transporters.
  • Validation of the suitability of selected transporters as potential novel drug targets (RNAi or CRISPR to determine essentiality for trypanosome survival).
  • Disruption of glycosomal targeting of transporters by block of interaction between Pex19 and sorting signal of membrane proteins (mPTS) as novel drug target.
  • Identification of mPTS in transporters, establishment of the in vitro interaction assay, drug/compound library screening (in cooperation with Novartis Pharma AG).

Location: Bochum, Germany
Supervisor: Prof. Dr. R. Erdmann (ralf.erdmannATrub.de)
Co-supervisor: Dr. D. Hoepfner, Novartis Pharma AG & Prof. Dr. H. R. Waterham, Academic Medical Centre at the University of Amsterdam
Planned secondments: University of Freiburg, Novartis Pharma AG, Academic Medical Centre at the University of Amsterdam
Required subject specific skills and expertise: a master’s degree in life sciences/biology (molecular cell biology, biochemistry, biomedicine). Experience in cell culture and fluorescence microscopy is advantageous but not mandatory.

Application deadline: 28/10/2018
Starting date:  April 1, 2019

Application form ESR6

The previous deadline for applications has been extended until October 28.

Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline

87 total views, 2 views today