A PhD position is available at the Laboratory Genetic Metabolic Diseases, Academic Medical Centre at the University of Amsterdam, The Netherlands.
Project title: Human peroxisomal metabolite/cofactor transporter proteins
- To identify potential human transporter proteins by proteomic analysis of purified human peroxisomal membranes.
- Identification of promising candidate proteins using bioinformatics.
- Validation of selected candidates and effect on metabolism (CRISPR, fluorescence microscopy and electron microscopy, cell fractionation, metabolomics);
- Functional analysis of novel and selected known transporter proteins in vivo to determine role in human metabolism (CRISPR, metabolite sensors, metabolomics);
- Identification and characterization of novel or previously described human disorders caused by defects in genes encoding peroxisomal metabolite transporter proteins (whole exome sequencing data and databases/bioinformatics);
- Search for compounds that can rescue or bypass human transporter defects in cells.
Location: Amsterdam, The Netherlands
Supervisor: Prof. Dr. H.R. Waterham (h.r.waterhamATamc.uva.nl)
Co-supervisors: Dr. D. Hoepfner, Novartis Pharma AG & Prof. Dr. M. Fransen, KU Leuven
Planned secondments: Novartis Pharma AG, KU Leuven, University of Exeter
Required subject specific skills and expertise: a master’s degree in life sciences/biology (molecular cell biology, biochemistry, biomedicine). Experience in mammalian cell culture and fluorescence microscopy is advantageous but not mandatory.
Application deadline: 28/10/2018
Starting date: April 1, 2019
The previous deadline for applications has been extended until October 28.
Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline
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