A PhD Position is available at the University of Exeter, Department of Biosciences, Exeter, United Kingdom
Project title: Modulating human organelle contacts to improve cell performance
- To generate fluorescence-based reporter systems to analyse peroxisome-organelle (mitochondria, ER) interactions;
- To determine physiological conditions which modulate organelle contacts, e.g. peroxisome-mitochondria interaction during oxidative stress.
- To perform compound screening to identify modulators of organelle contacts (supported by automated image analysis, LI).
- To analyse the impact of modulating organelle contacts on cell performance using cell models for oxidative stress and organelle dysfunction (measure organelle/mitochondrial parameters (Seahorse technology, lipid metabolism etc.).
Location: Exeter, United Kingdom
Supervisor: Prof. Dr. M. Schrader (m.schraderATexeter.ac.uk)
Co-supervisors: Dr. D. Hoepfner, Novartis Pharma AG & Prof. Dr. M. Fransen, KU Leuven
Planned secondments: KU Leuven, Novartis Pharma AG, MS-Omics ApS
Required subject specific skills and expertise: a master’s degree in life sciences/biology (molecular cell biology, biochemistry). Experience in mammalian cell culture, fluorescence microscopy, molecular cloning and protein biochemistry is advantageous but not mandatory.
Application deadline: 28/10/2018
Starting date: April 1, 2019
The previous deadline for applications has been extended until October 28.
Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline
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