ESR12-BE: Physiological targets of peroxisome-derived hydrogen peroxide

Reference: ESR12-BE

A PhD position is available at KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium

Project title: Physiological targets of peroxisome-derived hydrogen peroxide
Description:

  • To inventorize protein thiol targets of peroxisome-derived H2O2 in human cells;
  • To study the role of peroxisome-derived H2Oin retrograde signalling;
  • To assess how acute and chronic doses of peroxisome-derived H2Oaffect mitochondrial morphology (e.g. shape, number, size, positioning), function (e.g. respiration), and interorganellar contact sites;
  • To evaluate peroxisome and mitochondrial abundance and morphology in mammalian cells using artificial intelligence-based image analysis methods;
  • To examine how changes in peroxisome abundance and function alter the cellular protein thiol oxidation profile;
  • To validate the in cellulo findings in more disease-related cell types and tissues from control mice and mice suffering from peroxisomal deficiencies.

Location: Leuven, Belgium

Supervisor: Prof Dr. M. Fransen (marc.fransenATkuleuven.be)
Co-supervisors: Prof. Dr. E. Gnaiger, Oroboros Instruments GmbH & Prof. Dr. M. Schrader, University of Exeter
Planned secondments: Oroboros Instruments GmbH, University of Exeter, Lambert Instruments
Required subject specific skills and expertise: a master’s degree in life sciences (e.g., biomedical sciences, molecular cell biology, biochemistry, or biophysics). Experience in mammalian cell culture and fluorescence microscopy is advantageous but not mandatory.
Application deadline: 28/10/2018
Starting date:  April 1, 2019

Application form ESR12

The previous deadline for applications has been extended until October 28.

Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline

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