A PhD position is available at the University of Freiburg, Department of Biochemistry & Functional Proteomics, Freiburg, Germany
Project title: Dynamics and regulation of ER-peroxisome contact sites
- Mapping of in vivo phosphorylation sites in Pex30p-dependent ER-peroxisome contact sites (EPCONS) under different conditions in yeast using high-resolution mass spectrometry.
- Identification of kinases mediating phosphorylation events and their preferred target sites to decipher the cellular signalling pathway(s) regulating EPCON formation.
- Functional analysis of EPCONS using site mutants of selected proteins mimicking or preventing phosphorylation or targeting selected protein kinases and signalling pathways using conditional mutant strains or specific kinase inhibitors.
- Characterizing human PEX30 and its role for the formation of EPCONS.
Location: Freiburg, Germany
Supervisor: Prof. Dr. B. Warscheid (bettina.warscheidATbiologie.uni-freiburg.de)
Co-supervisors: Prof. Dr. L.R.B. Schomaker, Lambert Instruments & Prof. Dr. I.J. van der Klei, University of Groningen
Planned secondments: University of Exeter, Lambert Instruments, University of Groningen
Required subject specific skills and expertise: a master’s degree in biology, biochemistry or a related discipline. Experience in proteomics/mass spectrometry and molecular genetics is advantageous but not mandatory.
Application deadline: 27/1/2019
Starting date: April 1, 2019
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