ESR14-UK: The peroxisome-ER membrane contact site (MCS) in humans

Reference: ESR14-UK

A PhD Position is available at the University of Exeter, Department of Biosciences, Exeter, United Kingdom
Project title: The peroxisome-ER membrane contact site (MCS) in humans

  • To identify and characterise interaction partners and regulators of the novel peroxisome-ER MCS mediated by the ACBD4/5-VAPA/B tether in humans (bioinformatics, pull down assays, BioID2, mass spectrometry, molecular cell biology);
  • To develop and establish models and techniques for the analysis of lipid transfer between the ER and peroxisomes;
  • To validate selected candidates (CRISPR, fluorescence and quantitative electron microscopy, cell fractionation) and to reveal their physiological role in health and disease conditions;
  • To examine if mutations in MCS genes can be linked to a collection of fibroblasts obtained from patients with peroxisomal disorders whose genetic bases have not yet been identified.

Location: Exeter, United Kingdom
Supervisor: Prof. Dr. M. Schrader (
Co-supervisors: Dr. M. Danielsen, MS-Omics ApS & Dr. P. Kim, The Hospital for Sick Children
Planned secondments: The Hospital for Sick Children, Academic Medical Centre at the University of Amsterdam, MS-Omics ApS
Required subject specific skills and expertise: a master’s degree in life sciences/biology (molecular cell biology, biochemistry). Experience in mammalian cell culture, fluorescence microscopy and protein biochemistry is advantageous but not mandatory.
Application deadline: 18/08/2019
Starting date:  September 1, 2019

Application form ESR14

Please note: Applications that have already been submitted are well received and under consideration. No further action is required on behalf of applicants who applied before the previous deadline

714 total views, 1 views today

grant number 812968